Dose Information

Graph Information

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INVEGA TRINZA® Switching to Oral INVEGA®

Consistent with the Prescribing Information for INVEGA TRINZA® and INVEGA®:

• INVEGA TRINZA® is to be used only after INVEGA SUSTENNA® has been established as adequate treatment for at least four months.
• For switching from INVEGA TRINZA® to INVEGA®, the daily dosing of INVEGA® should be started 3 months after the last INVEGA TRINZA® dose and transitioned over the next several months following the last INVEGA TRINZA® dose as described in the table below. The table provides dose conversion regimens to allow patients previously stabilized on different doses of INVEGA TRINZA® to attain similar paliperidone exposure with INVEGA®.

INVEGA TRINZA® Doses and INVEGA® Conversion Regimens Needed to Attain Similar Paliperidone Exposures

	Weeks Since Last INVEGA TRINZA® Dose
	3 months to 18 weeks	Longer than 18 weeks to 24 weeks	Longer than 24 weeks
Last INVEGA TRINZA® Dose	Doses of INVEGA®
273 mg	3 mg	3 mg	3 mg
410 mg	3 mg	3 mg	6 mg
546 mg	3 mg	6 mg	9 mg
819 mg	6 mg	9 mg	12 mg

• The cumulative paliperidone plasma level curve will reflect the plasma level contributions from INVEGA TRINZA® and oral INVEGA® ER in this scenario.

INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]

INVEGA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA-pi.pdf]