Switching to Oral INVEGA® ER after 1st INVEGA TRINZA® injection
| Dose Information |
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Graph Information
INVEGA TRINZA® Switching to INVEGA®
Consistent with the Prescribing Information for INVEGA TRINZA® and INVEGA®:
- INVEGA TRINZA® is to be used only after INVEGA SUSTENNA® has been established as adequate treatment for at least four months.
- For switching from INVEGA TRINZA® to INVEGA®, the daily dosing of INVEGA® should be started 3 months after the last INVEGA TRINZA® dose and transitioned over the next several months following the last INVEGA TRINZA® dose as described in the table below. The table provides dose conversion regimens to allow patients previously stabilized on different doses of INVEGA TRINZA® to attain similar paliperidone exposure with INVEGA®.
INVEGA TRINZA® Doses and INVEGA® Conversion Regimens Needed to Attain Similar Paliperidone Exposures
| Weeks Since Last INVEGA TRINZA® Dose | |||
| 3 months to 18 weeks | Longer than 18 weeks to 24 weeks | Longer than 24 weeks | |
| Last INVEGA TRINZA® Dose | Doses of INVEGA® | ||
| 273 mg | 3 mg | 3 mg | 3 mg |
| 410 mg | 3 mg | 3 mg | 6 mg |
| 546 mg | 3 mg | 6 mg | 9 mg |
| 819 mg | 6 mg | 9 mg | 12 mg |
- The cumulative paliperidone plasma level curve will reflect the plasma level contributions from INVEGA TRINZA® and oral INVEGA® in this scenario.
INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]
INVEGA® Prescribing Information