Switching to INVEGA SUSTENNA® After 4th Dose of INVEGA TRINZA®
| Dose Information |
|---|
Graph Information
INVEGA TRINZA® Switching to INVEGA SUSTENNA®
Consistent with the Prescribing Information for INVEGA TRINZA® and INVEGA SUSTENNA®:
- INVEGA TRINZA® is to be used only after INVEGA SUSTENNA® (1-month paliperidone palmitate extended-release injectable suspension) has been established as adequate treatment for at least four months.
- For switching from INVEGA TRINZA® to INVEGA SUSTENNA®, INVEGA SUSTENNA® should be started 3 months after the last INVEGA TRINZA® dose, using the equivalent 3.5-fold lower dose as shown in the table below.
Conversion From INVEGA TRINZA® to INVEGA SUSTENNA®
| If the Last Dose of INVEGA TRINZA® is: | Initiate* INVEGA SUSTENNA® 3 Months Later at the Following Dose: |
| 273 mg |
78 mg |
| 410 mg |
117 mg |
| 546 mg |
156 mg |
| 819 mg |
234 mg |
- The
cumulative paliperidone plasma level curve
will reflect the plasma level contributions from the INVEGA TRINZA® treatment
and INVEGA SUSTENNA® in this scenario.
- INVEGA SUSTENNA® should then continue, dosed at monthly intervals.
- Administration: For intramuscular injection only by a healthcare professional. Care should be taken to avoid inadvertent injection into a blood vessel.
INVEGA TRINZA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+TRINZA-pi.pdf]
INVEGA SUSTENNA® Prescribing Information [http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/INVEGA+SUSTENNA-pi.pdf]