INVEGA TRINZA® Common Dosing and Administration Topics
Switching
From INVEGA TRINZA® to Oral INVEGA® ER
Consistent with the Prescribing Information for INVEGA TRINZA® and INVEGA®:
- INVEGA TRINZA® is to be used only after INVEGA SUSTENNA® has been established as adequate treatment for at least four months.
- For switching from INVEGA TRINZA® to INVEGA®, the daily dosing of the INVEGA® should be started 3 months after the last INVEGA TRINZA® dose and transitioned over the next several months following the last INVEGA TRINZA® dose as described in the table below. The table provides dose conversion regimens to allow patients previously stabilized on different doses of INVEGA TRINZA® to attain similar paliperidone exposure with INVEGA®.
INVEGA TRINZA® Doses and INVEGA® Conversion Regimens Needed to Attain Similar Paliperidone Exposures
|
Weeks Since Last INVEGA TRINZA® Dose |
|||
|
3 months to 18 weeks |
Longer than 18 weeks to 24 weeks |
Longer than 24 weeks |
|
|
Last INVEGA TRINZA® Dose |
Doses of INVEGA® |
||
|
273 mg |
3 mg |
3 mg |
3 mg |
|
410 mg |
3 mg |
3 mg |
6 mg |
|
546 mg |
3 mg |
6 mg |
9 mg |
|
819 mg |
6 mg |
9 mg |
12 mg |
For illustrative displays of this dosing scenario, please click the links below.