Rationale – Deltoid Administration for Initiation Doses

Consistent with the INVEGA SUSTENNA® Prescribing Information:

• Following intramuscular injection of single doses (39 mg - 234 mg) in the deltoid muscle, on average, a 28% higher Cmax was observed compared with injection in the gluteal muscle. The two initial deltoid intramuscular injections of 234 mg followed by 156 mg one week later help attain therapeutic concentrations rapidly. The release profile and dosing regimen of INVEGA SUSTENNA® results in sustained therapeutic concentrations.

For illustrative displays of this dosing scenario, please click the link(s) below.

Initiation Dosing for Schizophrenia

Standard Dosing for Schizophrenia